| Product name: |
CK16 Mouse mAb |
| Reactivity: |
Human, Rat, Mouse |
| Alternative Names: |
Cytokeratin 16, K16, K1CP, keratin 16, KRT16, KRT16A, NEPPK |
| Source: |
Mouse |
| Dilutions: |
IHC 1:200 |
| Immunogen: |
Synthetic Peptide |
| Storage: |
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid?repeated?freeze-thaw?cycles. |
| Clonality: |
Monoclonal |
| Isotype: |
IgG1 |
| Concentration: |
1mg/mL |
| Observed Band: |
51kDa |
| GeneID: |
3868 |
| Human Swiss-Prot No: |
P08779 |
| Cellular localization: |
Intermediate filament |
| Background: |
Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating. |
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